National Amateur Radio Organization of People's Republic of China.
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1 I crac k't out laughing when I heard tell o' such nonsense.
2 How these proteins interact to assemble functional CRAC channels has remained uncertain.
3 CRAC channels were visualized as fluorescent puncta in total internal reflection microscopy.
4 The latter defect emphasizes an important role of CRAC channels in tooth development.
5 This effect is reversed when cells are treated with a CRAC channel inhibitor.
6 The identity and activation mechanism of CRAC channels at a molecular level are unknown.
7 MIC channels differ from CRAC channels in several critical respects.
8 This hydrophobic gating mechanism has implications for CRAC channel function, pharmacology and disease-causing mutations.
9 We propose that Orai1 is an essential component or regulator of the CRAC channel complex.
10 Crac de Chevaliers was bombed by government fighter jets after rebel snipers took up position inside.
11 Defects in CRAC channel function are associated with serious human diseases such as immunodeficiency and auto-immunity.
12 CRAC channels are composed of ORAI1 proteins located in the plasma membrane, which form its ion-conducting pore.
13 Pore helix rotation by STIM1 also explains the dynamic coupling between CRAC channel gating and ion selectivity.
14 We recently used a two-pronged genetic approach to identify Orai1 as the pore subunit of the CRAC channel.
15 Here we review recent work addressing CRAC channel regulation, pore properties, and the search for CRAC channel genes.
16 These changes in ion selectivity provide strong evidence that Orai1 is a pore subunit of the CRAC channel.
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